cause bodily suffering to and make sick or indisposed
source: WordNet 3.0
To affect with pain or uneasiness, either physical or mental; to trouble; to be the matter with; -- used to express some uneasiness or affection, whose cause is unknown; as, what ails the man? I know not what ails him.
source: Webster 1913
To be affected with pain or uneasiness of any sort; to be ill or indisposed or in trouble.